The COBRE CMADP brings physical and biological scientists and engineers together in a unique manner by combining cutting-edge enabling technologies for the analysis of disease-related molecular pathways. In addition to an administrative core, CMADP has established three research core laboratories that enable a variety of research applications, allowing investigators to explore new pathways of the disease process.

Administrative Core

The Administrative Core provides coordination of the overall research effort and administrative leadership for CMADP as a whole.

photo of CMADP program manager and director

Genome Sequencing Core (GSC)

This core provides researchers with next-generation sequencing technologies, as well as experimental design and analysis of sequence data. The GSC is involved in the identification of genetic (genotypic) elements that underlie the disease and disease pathways. Projects in the GSC include whole genome assembly, genome re-sequencing for identification of mutations important in development and disease, transcriptome analysis (RNA seq), variant mapping and genotyping, and identification of transcription factor interaction sites using chromatin immunoprecipitation combined with DNA sequencing (ChIP seq).

researcher reading data from Illumina equipment

Synthetic Chemical Biology Core (SCB)

This core offers expert design of molecular probes and synthesis of both small molecules and peptides, with an emphasis on the generation of fluorescent and other tagged molecules, as well as bioassays of molecular probes. In addition to fluorescent probes, the SCB can synthesize known but commercially unavailable compounds necessary for biochemical studies. The SCB is a shared core laboratory supported by two COBRE centers at KU (CMADP and the COBRE Center for Chemical Biology of Infectious Disease (CBID)), leveraging resources from both COBREs to best provide investigators with comprehensive synthetic chemistry.

chemist working in hood in research laboratory

KU Nanofabrication Facility (KUNF)

This core makes resources and personnel available for the production of micro- and nanoscale devices to be used by project investigators for their studies. Equipment and training are available to investigators for the fabrication of devices for biomedical, biophysical, and bioanalytical studies related to disease pathways. Research applications for such devices include clinical diagnostics, pharmaceutical analysis, single-cell analysis, imaging, sensing, and biophysical applications, and broader applications in engineering, physics, and chemistry. This core laboratory, established upon CMADP's inception in 2012 as the Microfabrication and Microfluidics Core, was renamed in 2020 to the KU Nanofabrication Facility to better reflect the core laboratory's current capabilities.

gowned user at a hood in cleanroom