The Center for Molecular Analysis of Disease Pathways (CMADP) is a NIH Center of Biomedical Research Excellence (COBRE) created in July 2012 to encourage basic research scientists to develop and implement new enabling technologies for the study of biological pathways and processes related to disease. By providing mentor support and infrastructure, the Center also works to enhance the ability of junior investigators to compete independently for NIH individual research grants and other external peer-reviewed support.
The CMADP is comprised of four cores. The Administrative Core provides coordination of the overall research effort and administrative leadership for the Center as a whole. In addition, the Center features three research core facilities:
- the Genome Sequencing Core (GSC) for next-generation sequencing technologies, experimental design and analysis of sequence data,
- the Synthetic Chemical Biology Core (SCB) for design/synthesis of small molecules and peptides (especially fluorescent and other tagged molecules) and bioassays of molecular probes, and
- the KU Nanofabrication Facility (KUNF) for the production of unique nano/microfabricated devices for studying genetically modified organisms and biological pathways.
The Center is organized and directed out of the Ralph N. Adams Institute for Bioanalytical Chemistry in conjunction with the Higuchi Biosciences Center. CMADP is directed by Susan M. Lunte, Ralph N. Adams Distinguished Professor of Chemistry and Pharmaceutical Chemistry and director of the Adams Institute for Bioanalytical Chemistry. Dr. Lunte is assisted by Co-Investigator Erik Lundquist, a Professor of Neuroscience in the Department of Molecular Biosciences and an expert on genetics and the use of model organisms for the study of neurological disorders.
Assisting these investigators in guiding the progress of the Center are the External Advisory Committee (EAC), steering committees for each core facility, senior faculty mentors for each project investigator, and an internal evaluator (Robert Hanzlik, Emeritus Professor of Medicinal Chemistry and Director of the former COBRE Center in Protein Structure and Function at KU).
Aim #1: Provide an empowering administrative and core structure that facilitates the successful implementation of research projects on the development of enabling technologies for the study of disease processes.
Aim #2: Produce enthusiastic junior faculty with competitive independent research programs through personal mentoring, internal and external reviews of proposals, and short courses.
Aim #3: Promote scientific interactions among investigators, mentors, core leaders and interested scientists through monthly meetings, workshops and an biannual symposium.
Aim #4: Grow the scientific infrastructure in the state of Kansas through the continued support of new junior investigators, and enhance the capabilities of the CMADP's core laboratories by improving infrastructure, maximizing resources and increasing the user base to move towards sustainability.