chemist measuring solution into test tube

Center for Molecular Analysis of Disease Pathways

The Center for Molecular Analysis of Disease Pathways is an NIH Center of Biomedical Research Excellence (COBRE) focused on the creation and implementation of enabling technologies for the investigation of the genetic, biochemical and physical origins of disease.

Researchers reviewing scientific data in lab

Supporting Research Statewide

The Center for Molecular Analysis of Disease Pathways (CMADP) brings together junior and senior faculty from the physical, biological, and pharmaceutical sciences at the University of Kansas and other academic institutions in Kansas.

What We Do

Enabling technologies are critical for the understanding of the biochemical and physical basis of disease as well as its diagnosis. The COBRE CMADP pursues health-related research that is focused on the development and application of these technologies to understanding disease processes. Two of the Center’s major missions are to recruit, support and mentor outstanding junior faculty investigators, and to establish, operate, and grow successful Core Labs that provide state-of-the-art capabilities and services to investigators.

The COBRE CMADP capitalizes on the current strengths of KU in the fields of bioanalytical chemistry, molecular biology, synthetic chemistry, genomics and bioengineering. Three Core Labs were established during Phase 1 focused on providing enabling technologies for junior faculty investigators studying disease pathways: the Genome Sequencing Core, the Synthetic Chemical Biology Core and the KU Nanofabrication Facility (formerly the Microfabrication & Microfluidics Core). The three Cores have catalyzed biomedical research in the state of Kansas by enhancing the research of junior and senior faculty investigators and attracting faculty involved in biomedical research to Kansas Board of Regents institutions.

Core Laboratories

researcher working at Illumina instrument

Genome Sequencing Core

Next-Generation Sequencing (NGS) technology
Chemist performing an experiment under a hood in a laboratory

Synthetic Chemical Biology Core

Molecular probe synthesis capabilities
Researcher performing experiment in cleanroom while wearing a suit

KU Nanofabrication Facility

Micro/Nanofluidic device design and fabrication

Research reported in this website is supported by two Institutional Development Awards (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under Award Numbers P20GM103638 and P30GM145499. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.