The COBRE CMADP was created in July 2012 to encourage basic research scientists to develop and implement new enabling technologies for the study of biological pathways and processes related to disease. By providing mentor support and infrastructure, the Center also seeks to enhance the ability of junior investigators to compete independently for NIH individual research grants and other external peer-reviewed support.

CMADP Leadership: Peterson, Lunte, Lundquist

The Center is organized and directed out of the Ralph N. Adams Institute for Bioanalytical Chemistry in conjunction with the Higuchi Biosciences Center. CMADP is directed by Susan M. Lunte, Ralph N. Adams Distinguished Professor of Chemistry and Pharmaceutical Chemistry and director of the Adams Institute for Bioanalytical Chemistry. Dr. Lunte is assisted by Co-Investigators, Blake Peterson, Regents Distinguished Professor of Medicinal Chemistry and Erik Lundquist, Professor of Molecular Biosciences. Dr. Peterson is an internationally recognized researcher in the development of novel fluorescent probes and chemical tools for studies of drug delivery, transport, and control of protein function. Dr. Lundquist is an Professor of Neuroscience in the Department of Molecular Biosciences and is an expert on genetics and the use of model organisms for the study of neurological disorders.

Assisting these investigators in guiding the progress of the Center are the External Advisory Board (EAB), the Internal Advisory Board (IAB), steering committees for each core facility, and an internal evaluator (Robert Hanzlik, Professor of Medicinal Chemistry and Director of the COBRE Center in Protein Structure and Function at KU).

Four specific aims guide the research at the Center:

  1. Specific Aim 1: Provide an empowering administrative and core structure that facilitates the successful implementation of research projects on the development of enabling technologies for the study of disease processes
  2. Specific Aim 2: Produce enthusiastic junior faculty with competitive independent research programs through personal mentoring, internal and external reviews of proposals, and short courses;
  3. Specific Aim 3: Promote scientific interactions among investigators, mentors, core leaders and interested scientists through monthly meetings, workshops and an annual symposium
  4. Specific Aim 4: Grow the scientific infrastructure in the State of Kansas for the Molecular Analysis of Disease Pathways through the continued support of new junior investigators, advertisement of the capabilities of the cores to potential users and renovation of space to house core facilities

In order to support and encourage these types of interactions, the Center features three core facilities in addition to the Administrative Core. These are:

  1. the Genome Sequencing Core (GSC) for next-generation sequencing technologies, experimental design and analysis of sequence data,
  2. the Synthetic Chemical Biology Core (SCBC) for design/synthesis of small molecules and peptides (especially fluorescent and other tagged molecules) and bioassays of molecular probes, and
  3. the Microfabrication and Microfluidics Core (MMC) for the production of unique microfabricated devices for studying genetically modified organisms and biological pathways.

The following projects have been chosen based on their relevance to the theme of the proposal and the credentials of the young investigators:

Current Research Projects

Current Pilot Projects

Past Research Projects (2012-2017)

Past Pilot Projects (2013-2016)

Recent News

June 2018
Mei He's review article selected for journal cover of Lab on a Chip

May 2018
Arghya Paul earns departmental teaching award
Yong Zeng promoted to associate professor with tenure

March 2018
Sue Lunte to receive 2018 ANACHEM Award
Christian Ray selected to co-organize international conference

View all news »

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