Single wall carbon nanotube platforms as near-infrared fluorescent sensors
Prof. Shenqiang Ren, Department of Chemistry
University of Kansas
Project dates: 2013-2014
The research objective of this proposal is to establish the single wall carbon nanotubes (SWCNTs) platform for adenosine 5’-triphosphate (ATP) and glucose sensing. Molecular recognition plays an important role in the design of therapeutics and sensing platforms. The research strategy is to explore functionalized single-chirality SWCNT platforms as new type molecular recognition motif, by using a binding pocket or interface to recognize the specific molecule. The project will be comprised of the following interrelated sub-programs: (1) Explore the design rules for building single-chirality SWCNT NIR fluorophore biosensor; (2) Understand the mechanism and relationship between structure and fluorescent emission changes of SWCNT by the target analyte binding, such as the wavelength and intensity changes due to charge-transfer, exciton quenching or solvatochromism. Biosensors based on the modulation of single-chirality SWCNT photoemission will demonstrate real time spatio-temporal detection.