Administrative Core

The Administrative Core is responsible for the organizational aspects of the COBRE including reviewing proposals for funding, budgeting, coordination of seminars and short courses, IAC, and EAB. Three scientific Core facilities are supported within the CMADP. These scientific Cores are supported through investments in personnel, supplies, and equipment and interact directly with the principal investigators to help them accomplish their projects. The overall structure of CMADP is shown below.

All Project grant recipients are selected for participation in the CMADP-funded program based on submission of their proposals for review by external experts, receipt of a favorable recommendation for funding by the external reviewers, and final support of such recommendation by both the Internal Advisory Committee (IAC) and the External Advisory Board (EAB) of CMADP. Prior to finalizing decisions on funding such Project Grants, the PI and Co-Is will submit the Project proposals and reviews to NIGMS Program Officers for review and approval. It is expected that there will be a greater number of proposals submitted for funding than will ultimately receive funding from CMADP. Core A will also organize the external review of proposals for project funding, and the communication of results from Projects and scientific Cores through the sponsorship of scientific meetings and symposia.

Contact Us:

COBRE CMADP
Multidisciplinary Research Building (MRB)
2030 Becker Drive, Room 220
Lawrence, KS 66047
Susan M. Lunte, PI & Administrative Core Leader, slunte@ku.edu, 785-864-3811
Cady Bush, Program Coordinator, cbush@ku.edu, 785-864-2342


Recent News

February 2017
CMADP Project Investigators co-author Top Downloaded article in Lab on a Chip

CMADP Co-I awarded R01 from NIH National Cancer Institute

CMADP Graduate's research featured on cover of Genetics and in other journals

October 2016
CMADP Co-I receives Mathers Foundation grant

View all news »

Upcoming Events
Special seminar by Dr. James P. Landers
Commonwealth Professor in Chemistry,
Mechanical Engineering & Pathology
University of Virginia

Wednesday, May 17, 2017 at 3:00pm
Simons Auditorium, HBC, West Campus

"Integrated Microfluidic Systems for Forensic DNA Analysis"
In 2006, we demonstrated that microfluidic technology could provide a ‘lab-on-a-chip’ solution for real-world genetic analysis. Sample-in/answer-out functionality was shown for the detection of bacteria in mouse blood and in a human nasal swab, with a sub-30 minute analytical time for DNA extraction, amplification, electrophoretic separation and detection. We extrapolated these technology developments to the analysis of short tandem repeats (STR) in human DNA; these clinically-insignificant (presumably) tetranucleotide sequences function effectively for statistically-relevant matching in human identification. Our efforts led to the development of a commercializable system designed for implementation in crime labs for STR profiling convicted felons or, in some states, profiling arrestees in booking stations. An intricate but functional microfluidic architecture allowed sample-to-profile to be achieved from a cheek swab in less than 80 minutes, using nanoliter flow control, infrared thermocycling and rapid electrophoretic separation of DNA with 5-color fluorescence detection. We have since demonstrated the fabrication of hybrid microdevices composed of inexpensive polymeric materials, many of these commercial-off-the-shelf. We have designed, built and functionalized fully-integrated DNA analysis chemistry/microfluidics on a rotationally-driven system the size of a compact disc. With this system, DNA can be extracted from a swab, PCR amplified to generate an abundance of DNA fragments of the STR loci, followed by resolution of those fragments in a separation in a 4 cm Leff channel that is complete in <300 sec with a 2-base resolution. The processes that allow for swab in–profile out microfluidics are carried out on an instrument that can be carried in one hand and weighs ~14 lbs, ultimately allowing for facile rapid human identification/screening in the field.
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